Injectable and self?healing biobased composite hydrogels as future anticancer therapeutic biomaterials

Self-healing composite hydrogels are prepared from sustainable biopolymers by a green chemistry approach and analyzed physicochemical mechanical characterization techniques for future injectable anticancer biomaterials. Water-soluble chitosan (WSC) was grafting polyethylene glycol (PEG), glutamic acid gallic onto the chain carbodiimide chemistry. This WSC showed fast gelation (t ? < 60 seconds) with benzaldehyde-terminated 4-arm-PEG as crosslinker through an amine/aldehyde Schiff base reaction. The compression modulus of these gels can be controlled between 6 67 kPa, which dependent on both content well total solid (T%). It injectability complete self-healing ability at lower (T = 2%). hydrogel nanocomposites (HNCs) were synthesized together gold (Au) silver (Ag) nanoparticles (NPs) tested cytotoxicity using fibroblast cells (WI-38) 48 hours, good biocompatibility. in-vitro assay against cancer (U87MG) hours indicated that only HNCs incorporated AuNPs effective agents cell apoptosis in contrast to pristine gel, pure NPs (Ag AuNPs) HCNs AgNPs. Therefore, could chemotherapeutic materials designing nanomedicines future.